Sign of Leser-Trélat. Authoritative facts about the skin from DermNet New Zealand. Leser-Trélat sign is a rare skin condition characterized by the sudden appearance of seborrheic keratoses that rapidly increase in number and size within weeks. Images in Clinical Medicine from The New England Journal of Medicine — The Sign of Leser–Trélat.

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There is no reported increased predilection amongst either sex or any race. Safa G, Darrieux L. The criteria are as follows: Erythema gyratum repens Necrolytic migratory erythema. Obtaining a thorough history, review or systems, and physical examination may help tgelat the workup of the patient towards a certain malignancy. Images in clinical medicine. Create a free personal account to access your subscriptions, sign up for alerts, and more.

Although these lesions are typically zign easy to distinguish from other melanocytic neoplasms, the histopathological examination may be required for lesions lacking typical exam findings.

The typical morphology of these lesions tends to vary extensively amongst patients and may present as a macule, papules, and plaques.

Published by Wolters Kluwer – Medknow. Curth’s postulates are a well-known set of clinical criteria that were created to help evaluate the temporal relationship between an underlying malignancy and a specific dermatological condition. In addition, symptomatic lesions may be destroyed with various physical methods including cryotherapy, curettage, shave removal, and electrodesiccation. Kurzrock R, Cohen PR.


Indian J Dermatol Venereol Leprol ; Bernett ; George J. It is likely that various cytokines and other growth factors produced by the neoplasm are responsible for the abrupt appearance of the seborrheic keratoses. Paraneoplastic dermatological manifestation of gastrointestinal malignancies.

Malignant Neoplasms and the Leser-Trélat Sign | JAMA Dermatology | JAMA Network

Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more. N Engl J Med ; Any of these distinct variations may also become irritated or inflamed, displaying either squamous eddy formation spindled cells or lymphocyte infiltration, respectively.

Sign in to make a comment Sign in to your personal account. A case of hepatocellular carcinoma with the sign of Leser-Trelat: This book is distributed under the terms of the Creative Commons Attribution 4.

By using this site, you agree to the Terms of Use and Privacy Policy. Purchase access Subscribe to the journal. Introduction The sign of Leser-Trelat is considered to be a fairly rare paraneoplastic cutaneous marker of internal malignancy with the hallmark finding being an abrupt eruption of multiple seborrheic keratoses.

Register for email alerts with links to free full-text articles Access PDFs of free articles Manage your interests Save searches and receive search alerts. Other cancers where the condition has occurred include squamous cell carcinomalymphoma and leukaemia. Get free access to newly published articles.

Views Read Edit View history. Seborrheic keratoses SK are a nearly trslat benign skin lesion in patients greater than 40 years of age, and generally, even healthy patients may have multiple seborrheic keratoses.


CA Cancer J Clin. The sign of Leser-Trelat. Show details Treasure Island FL: Sign in to download free article PDFs Sign in to access your subscriptions Sign in to your personal account. Multiple eruptive seborrheic keratoses on the a face and neck, b breast, and c back Click here to view.

This page was last edited on 11 Octoberat Leser-Trelat sign with primary hepatic carcinoma. How to cite this URL: Eruptive seborrheic keratoses associated with erythrodermic pityriasis rubra pilaris. StatPearls Publishing; Jan. Am J Med ; Cutaneous manifestations of internal malignancy. Although the back is the most common location, additional sites may include the sifn, face, neck, and lezer. Jpn J Med ; The associated cancer is often advanced and the average survival of these patients is approximately Seborrheic keratoses and cancer.

There does not appear to be an increased frequency of a specific histopathological variation of seborrheic keratoses that correlates with the sign of Leser-Trelat.

Dermatologic signs Paraneoplastic syndromes.

Leser–Trélat sign

Questions To access free multiple choice questions on this topic, click here. The criteria are as follows:. Click on image for details. Retrieved from ” tre,at J Am Acad Dermatol. Seborrheic keratoses of florid eruption.